|
Symbol Name ID |
Itgb3
integrin beta 3 MGI:96612 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating IgA level |
Increased circulating IgE level |
Abnormal bleeding |
Epistaxis |
Spontaneous, recurrent epistaxis |
Excessive bleeding from superficial cuts |
Gingival bleeding |
Gastrointestinal hemorrhage |
Intracranial hemorrhage |
Subdural hemorrhage |
Joint hemorrhage |
Menorrhagia |
Persistent bleeding after trauma |
Prolonged bleeding after surgery |
Prolonged bleeding following circumcision |
Prolonged bleeding time |
Bruising susceptibility |
Purpura |
Ecchymosis |
Petechiae |
Spontaneous hematomas |
Abnormal megakaryocyte morphology |
Increased megakaryocyte colony forming unit count |
Anemia |
Anemia of inadequate production |
Poikilocytosis |
Acanthocytosis |
Leukocytosis |
Acute myeloid leukemia |
Impaired ristocetin-induced platelet aggregation |
Impaired platelet aggregation |
Impaired ADP-induced platelet aggregation |
Impaired arachidonic acid-induced platelet aggregation |
Impaired collagen-induced platelet aggregation |
Impaired collagen-related peptide-induced platelet aggregation |
Impaired epinephrine-induced platelet aggregation |
Impaired thrombin-induced platelet aggregation |
Impaired thromboxane A2 agonist-induced platelet aggregation |
Decreased platelet glycoprotein IIb-IIIa |
Impaired clot retraction |
Abnormal platelet count |
Thrombocytopenia |
Congenital thrombocytopenia |
Intermittent thrombocytopenia |
Macrothrombocytopenia |
Abnormal platelet shape |
Abnormal platelet volume |
Decreased mean platelet volume |
Giant platelets |
Platelet anisocytosis |
| Disease(s) Associated with ITGB3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| acute myeloid leukemia | ||||||||||||||||||||||||||||||||||||||||||||||||||
| autoimmune thrombocytopenic purpura | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Glanzmann's thrombasthenia | ||||||||||||||||||||||||||||||||||||||||||||||||||
| platelet-type bleeding disorder 16 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| thrombocytopenia |
| Mouse Phenotypes | abnormal osteoclast differentiation |
impaired macrophage chemotaxis |
enlarged spleen |
extramedullary hematopoiesis |
anemia |
decreased erythrocyte cell number |
decreased hematocrit |
decreased hemoglobin content |
increased mean corpuscular hemoglobin |
increased mean corpuscular volume |
decreased macrophage cell number |
decreased osteoclast cell number |
increased osteoclast cell number |
increased monocyte cell number |
reticulocytosis |
abnormal osteoclast morphology |
increased IgG level |
abnormal macrophage physiology |
abnormal osteoclast physiology |
abnormal platelet physiology |
abnormal platelet activation |
decreased platelet aggregation |
abnormal platelet dense granule physiology |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||
| Itgb3tm1Aja/Itgb3tm1Aja | ||||||||||||||||||||||||
| Itgb3tm1Hyn/Itgb3tm1Hyn | ||||||||||||||||||||||||
| Itgb3tm1Mgin/Itgb3tm1Mgin | ||||||||||||||||||||||||
| Itgb3tm2Mgin/Itgb3tm2Mgin | ||||||||||||||||||||||||
| Itgb3tm1Hyn/Itgb3tm1.1Wlbcr Lyz2tm1(cre)Ifo/Lyz2+ (conditional) |
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| Itgb3tm1Hyn/Itgb3tm1.1Wlbcr Tg(Pf4-icre)Q3Rsko/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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